In this Deep Dive session, Drs Joshua Karunakaram, Yadhia Maharaj and Sharlene Parasnath give a detailed discussion on Acute Promyelocytic Leukaemia (APL). Particular focus is on its pathophysiology, coagulopathy, and treatment strategies. The speakers also discuss the challenges of managing APL, including early death rates, the impact of COVID-19, and potential strategies to improve patient outcomes.