In this Deep Dive Session, Prof. Adrian Brink, Dr. Jonathan Oxley-Oxland and Dr. Sean Wasserman discuss the challenges and strategies in managing infections in patients with hematological malignancies. Dr. Oxley-Oxland presents a case study of a patient with a complex infection, highlighting the difficulties in diagnosis and treatment. Dr. Brink and Dr. Wasserman provide an in-depth discussion on the use of various antibiotics, including colistin, tigecycline, and keftazidime-avibactam, emphasizing the importance of antibiotic stewardship and multidisciplinary approach in managing these complex cases.